Effective treatments for depression and coronary artery disease

Photo of an elderly couple sitting on a bench by the sea

Many people who have coronary artery disease (CAD) also develop . Depression can make heart problems worse too. Psychological treatment and certain antidepressants can relieve that develops after distressing events like a or surgery.

Coronary artery disease (CAD) is caused by a narrowing of the blood vessels that supply the muscles of the heart (coronary arteries). This means that the heart doesn't get enough oxygen because the blood vessels allow less blood to flow through. Coronary artery disease can lead to chest pain, a heart attack, heart failure and an irregular heartbeat. Many people who have coronary artery disease also develop depression.

Heart disease can cause depression

Depression that is linked to coronary artery disease is particularly common after a . Research has shown that about 15 to 20% of people who have to stay in hospital for treatment will develop afterwards. Sometimes will affect your emotional or physical wellbeing even months or years after a .

Depression increases the risk of heart problems

Health problems like heart attacks increase the risk of . On the other hand, long-lasting can also increase the likelihood of heart disease. It slows recovery from heart disease too, and can increase the risk of disease and death. There are various biological mechanisms that might make affect the heart directly. But specific behavioral habits that are more common in people with might also play a role, such as smoking or not getting enough exercise.

Research on psychological treatments and medications

Options for psychological treatment of include cognitive behavioral therapy, systemic therapy and psychoanalysis. You can also seek psychological support or counseling. Medications known as antidepressants are available as well.

Various studies have looked into how to relieve the symptoms of in people who have coronary artery disease. These studies tested the benefits of psychological treatments and medications. All of the participants in the studies had serious heart problems: Most of them had recently had a or surgery. Some people who had episodes of chest pain (angina pectoris) were also included.

The benefits of psychological treatments

The studies suggest that psychotherapy can relieve following a or surgery. These interventions also improved quality of life. These studies focused mostly on a brief form of cognitive behavioral therapy. This type of therapy helps you learn how to change your behaviors and attitudes, work on current problems, and find concrete solutions. It is not clear whether psychological treatment can lower the risk of developing heart disease again over the long term, though.

Benefits of medication

Antidepressants were also found to reduce in people with coronary artery disease. They are often combined with psychological treatments. But the medications are usually only suitable for moderate to severe . Most of the studies tested one specific group of antidepressants known as selective serotonin reuptake inhibitors (SSRIs). While SSRIs are suitable for people with heart problems, other antidepressants such as tricyclic antidepressants and monoamine oxidase inhibitors (MAOI) are not.

Ostuzzi G, Turrini G, Gastaldon C et al. Efficacy and acceptability of antidepressants in patients with ischemic heart disease: systematic review and meta-analysis. Int Clin Psychopharmacol 2019; 34(2): 65-75.

Tully PJ, Ang SY, Lee EJ et al. Psychological and pharmacological interventions for depression in patients with coronary artery disease. Cochrane Database Syst Rev 2021; (12): CD008012.

IQWiG health information is written with the aim of helping people understand the advantages and disadvantages of the main treatment options and health care services.

Because IQWiG is a German institute, some of the information provided here is specific to the German health care system. The suitability of any of the described options in an individual case can be determined by talking to a doctor. informedhealth.org can provide support for talks with doctors and other medical professionals, but cannot replace them. We do not offer individual consultations.

Our information is based on the results of good-quality studies. It is written by a team of health care professionals, scientists and editors, and reviewed by external experts. You can find a detailed description of how our health information is produced and updated in our methods.

Comment on this page

What would you like to share with us?

We welcome any feedback and ideas - either via our form or by gi-kontakt@iqwig.de. We will review, but not publish, your ratings and comments. Your information will of course be treated confidentially. Fields marked with an asterisk (*) are required fields.

Please note that we do not provide individual advice on matters of health. You can read about where to find help and support in Germany in our information “How can I find self-help groups and information centers?

Über diese Seite

Updated on April 15, 2024

Next planned update: 2027

Publisher:

Institute for Quality and Efficiency in Health Care (IQWiG, Germany)

How we keep you informed

Follow us on Twitter or subscribe to our newsletter or newsfeed. You can find all of our films online on YouTube.