In 2019, the Institute for Quality and Efficiency in Health Care (IQWiG, Germany) looked into the advantages and disadvantages of galcanezumab when compared with standard treatments for migraine in adults.
The manufacturer provided studies involving people who had tried at least two treatments without success. The researchers analyzed the data from a total of 218 people from three studies. These studies involved a total of 70 people who had treatment with galcanezumab and 148 people who were given a placebo. Both groups also received best supportive care and had treatment for 3 to 6 months, depending on the study. Patients in two of the studies had migraines for an average of about 9 days a month, while patients in the third study had migraines for about 20 days a month. The study showed the following results in these patients:
What are the advantages of galcanezumab?
Migraine days per month: The studies suggest that galcanezumab has an advantage here. After starting treatment with galcanezumab, the number of migraine days decreased by half or more in about 51 out of 100 people. This was the case in only about 12 out of 100 people who received a placebo.
In terms of improvement of migraine symptoms, the studies also suggest that galcanezumab has an advantage compared with a placebo.
What are the disadvantages of galcanezumab?
Galcanezumab wasn’t found to have any disadvantages compared with the placebo.
No difference
There was no difference between the treatments in terms of the following aspects:
- Severity of migraine
- Severe side effects
- Treatment stopped due to side effects
Health-related quality of life: No relevant difference was found between galcanezumab and the placebo in terms of everyday and social activities, work, concentration, as well as negative effects of migraine on mood.