Hepatitis B: Should I have the vaccine?

Photo of a man being vaccinated

In most adults, an acute hepatitis B will usually clear up on its own, without treatment. If it becomes chronic, though, it can have serious consequences. There is a vaccine to prevent hepatitis B. It is recommended for all babies and toddlers, as well as for adults who have a high risk of becoming infected.

The hepatitis B is mainly spread through blood, but also through other body fluids. This usually happens during unprotected sex – most commonly between men who have sex with other men. Having several sexual partners and recurring sexual STIs (sexually transmitted infections) can increase the risk of getting hepatitis B too. Other routes of include using non-sterile syringes when injecting drugs or having a tattoo done with non-sterile needles.

If a pregnant woman has hepatitis B, she might pass it on to her baby while giving birth. In Germany and other countries, pregnant women are offered a hepatitis B test to see whether they are infected.

The likelihood of becoming infected is generally quite low in countries like Germany, where less than 1 out of 100 people have hepatitis B.

In adults, the body usually fights off the virus successfully

In more than 95 out of 100 adults who are infected with hepatitis B, the can effectively fight the . If the clears up on its own, the can no longer be detected in the blood after six months. Sometimes small amounts of the remain in liver cells but they don’t cause any problems.

Acute hepatitis B infections only very rarely lead to long-term health issues. If someone has had hepatitis B in the past and recovered from it, it means that their has made antibodies that will most likely keep the under control. A hepatitis B that lasts longer than six months is considered to be chronic. Over time, chronic hepatitis B can lead to liver damage (liver cirrhosis) and liver cancer. These serious liver diseases don’t necessarily cause noticeable symptoms, or the symptoms may be non-specific.

Babies and children have a lower risk of . But if they’re infected, they react more sensitively to the hepatitis B virus and the is more likely to become chronic: Only about 10 out of 100 babies and children who are infected with hepatitis B are able to successfully fight the . In other words, the becomes chronic in about 90 out of 100 babies and children who have it.

Vaccine recommended for high-risk groups and young children

In Germany, the Standing Committee on Vaccination (Ständige Impfkommission, STIKO) at the Robert Koch Institute is responsible for issuing recommendations about vaccines. They recommend that adults have the hepatitis B vaccine if they have certain risk factors – for instance, if they

  • are more likely to come into contact with the hepatitis B due to their job or voluntary work (for instance, medical staff, police or first aiders),
  • are in close contact with someone who has a chronic hepatitis B (such as a relative),
  • have an illness that means that a hepatitis B could have more serious consequences (for instance, people who have HIV or a chronic liver disease, or people who need dialysis or regular blood transfusions),
  • use syringes to inject drugs,
  • have many different sexual partners and are a man who has sex with other men,
  • travel to a country where hepatitis B is very common.

STIKO also recommends that all babies and toddlers be vaccinated against hepatitis B. For this purpose, there is a combination vaccine that also offers protection against other diseases such as diphtheria, tetanus, polio, whooping cough and haemophilus influenzae type b. Depending on the exact type of vaccine, 3 or 4 injections are needed to achieve enough protection. Teenagers who haven’t yet been vaccinated are advised to have the vaccine.

In Germany, statutory health insurers pay for all people under the age of 18 to have the vaccines recommended by STIKO. Coverage of high-risk groups or travel vaccinations varies from insurer to insurer, but most statutory health insurers pay for them. If someone would like to be vaccinated against hepatitis because they are traveling to a high-risk area, they are usually given a combination vaccine against both hepatitis A and hepatitis B. You will find more information about travel vaccinations on the website of the World Health Organization.

How well is the hepatitis B vaccine tolerated?

The hepatitis B vaccine is well tolerated. There are no known severe side effects in healthy people.

But the vaccine isn’t suitable for people

  • who have an acute illness that is associated with a high fever or needs to be treated. For instance, people shouldn’t be vaccinated if they have the flu. They can have the vaccine later instead.
  • who had an overly sensitive reaction to a previous hepatitis B .

Cornberg M, Protzer U, Petersen J, Wedemeyer H, Berg T, Jilg W et al. Aktualisierung der S3-Leitlinie zur Prophylaxe, Diagnostik und Therapie der Hepatitis-B-Virusinfektion. AWMF-Register-Nr.: 021-011. Z Gastroenterol 2011; 49: 871–930.

Gemeinsamer Bundesausschuss (G-BA). Richtlinien des Gemeinsamen Bundesausschusses über die ärztliche Betreuung während der Schwangerschaft und nach der Entbindung („Mutterschafts-Richtlinien“). April 21, 2016.

Institute for Quality and Efficiecy in Healthcare (IQWiG, Germany). Screening for hepatitis B: Final report; Commission S16-03. November 14, 2018.

McDonald JW, Burroughs AK, Feagan BG, Fennerty MB (Ed). Evidence-Based Gastroenterology and Hepatology. Hoboken: Wiley-Blackwell; 2010.

Poethko-Müller C, Schmitz R. Impfstatus von Erwachsenen in Deutschland. Ergebnisse der Studie zur Gesundheit Erwachsener in Deutschland (DEGS1). Bundesgesundheitsbl 2013; 56: 845–857.

Robert Koch-Institut (RKI). Empfehlungen der Ständigen Impfkommission (STIKO) am Robert Koch-Institut – 2017/2018. August 24, 2017. (Epidemiologisches Bulletin; Volume 34).

Robert Koch-Institut (RKI). RKI-Ratgeber: Hepatitis B und D. May 20, 2016.

Trepo C, Chan HL, Lok A. Hepatitis B virus infection. Lancet 2014; 384(9959): 2053-2063.

IQWiG health information is written with the aim of helping people understand the advantages and disadvantages of the main treatment options and health care services.

Because IQWiG is a German institute, some of the information provided here is specific to the German health care system. The suitability of any of the described options in an individual case can be determined by talking to a doctor. informedhealth.org can provide support for talks with doctors and other medical professionals, but cannot replace them. We do not offer individual consultations.

Our information is based on the results of good-quality studies. It is written by a team of health care professionals, scientists and editors, and reviewed by external experts. You can find a detailed description of how our health information is produced and updated in our methods.

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Please note that we do not provide individual advice on matters of health. You can read about where to find help and support in Germany in our information “How can I find self-help groups and information centers?

Created on May 23, 2019
Next planned update: 2022


Institute for Quality and Efficiency in Health Care (IQWiG, Germany)

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