So far, only a few studies have looked into topical nail fungus treatments with nail polishes or creams. Because these studies had weaknesses, the results should be interpreted with caution. Amorolfine has not yet been well studied. Ciclopirox polish and treatment sets with urea and bifonazole cream were tested in a few studies.
Research on the effectiveness of nail polish containing ciclopirox showed that, after one year:
- About 10 out of 100 people who did not use ciclopirox no longer had a detectable fungal nail infection.
- About 30 out of 100 people who used ciclopirox no longer had a detectable fungal nail infection.
In other words, treatment with ciclopirox got rid of the fungal infection in about 22 out of 100 people. But even if the fungus had gone away, the cosmetic result wasn’t always satisfying. The nails only looked healthy after treatment in 7 out of 100 people.
Treatment with sets containing urea and bifonazole cream was tested in one study. It was compared with a treatment in which only urea cream was applied and the nail was removed, but without applying bifonazole cream afterwards. Three months after treatment was completed, it was found that:
- No fungus was visible or detectable in about 41 out of 100 people who only used urea cream.
- No fungus was visible or detectable in about 51 out of 100 people who used both urea and bifonazole cream.
In other words, the combination of urea and bifonazole got rid of nail fungus in an extra 10 participants. But there was no difference between the two groups six months after treatment. Also, the fungal infection returned in many participants, so it’s likely that neither of the two treatments can increase the chances of getting rid of the fungus in the long term.
People did not take part in the study if their fungal infection covered more than half of the affected nail area or if the infection started at the base of the nail.