Oral thrush

At a glance

  • Oral thrush is caused by types of yeast fungus that live in the mucous membranes lining your mouth.
  • It often develops if your immune system is weakened. This can happen as a result of cancer treatment, for instance.
  • Common signs of oral thrush are a white coating that covers your mouth and a fuzzy feeling in your mouth. It can also affect your sense of taste.
  • Antimycotics (anti-fungal medication) are used to treat oral thrush.

Introduction

Photo of a woman drinking a glass of water

Oral thrush is a condition that can be difficult to recognize at first. It is usually harmless and not necessarily painful, but it can be very unpleasant. Oral thrush is caused by types of yeast fungus called Candida that live in the mucous membranes lining your mouth. Its medical name “oral candidiasis” is taken from this fungus. Oral thrush is most often caused by a type of Candida fungus called Candida albicans.

Most people have small amounts of Candida on the mucous membranes lining their mouth and it usually doesn’t cause any noticeable problems. But given the right conditions, the fungus can start growing very quickly. This often affects people who have a weakened immune system, and it can also be a side effect of certain types of treatment.

Symptoms

Oral thrush is visible as a white coating that covers your mouth and throat. Scraping it off with a tongue depressor will reveal inflamed red areas that often bleed slightly as well. Even if they practice good oral hygiene, people who have oral thrush will notice a constant cottony feeling in their mouth. Their sense of taste will also be affected and they may have pain or a burning sensation on their tongue. That can make it difficult to eat and drink. Severe oral thrush can also affect your ability to swallow or speak.

Causes and risk factors

Oral thrush is usually the result of certain medical conditions or a side effect of medical treatment. Infections are generally more likely to occur if the body and are weakened. A very dry mouth makes it easier for the fungus to grow.

Oral thrush can result from cancer treatment. Chemotherapy can damage the mucous membranes and weaken the , allowing the fungus to spread more easily. This mostly affects people having high-dose chemotherapy, to treat leukemia for instance. Stem cell transplants and radiotherapy in the head and neck area also increase the risk.

People who have had an organ transplant are also very vulnerable. People with HIV/AIDS are especially at risk if they don’t receive adequate antiviral treatment.

Diabetes can also increase the risk of oral thrush, as can dentures and certain medications like steroid sprays and broad-spectrum used for several weeks at a time. Oral thrush is more common in older people who require nursing care and are generally very weak overall, eat and drink very little or are fed through a tube.

Effects

Oral thrush usually doesn’t cause any serious health problems, but it can be very unpleasant. If the fungus spreads to your food pipe, for example, it may cause problems swallowing. Together with the other symptoms, this may cause people who have oral thrush to eat less and lose weight. That's mostly a problem if they are already weakened by another medical condition or a treatment, or if they also have other problems like nausea or lack of appetite.

Left untreated, oral thrush can last for months or even years. If your is very weak, the fungi may penetrate deeper layers of tissue, reaching the circulatory system and causing life-threatening sepsis. But this only rarely happens.

Diagnosis

If you have a higher risk of developing oral thrush, it’s important to tell your doctor or caregiver about any unusual sensations or pain you may feel in your mouth. They could then check whether it’s a fungal . If they think it might be oral thrush, a sample of the coating can be taken using a sterilized cotton swab and then tested in a laboratory.

Oral thrush can be discovered earlier in people who have cancer or HIV/AIDS if they have their mouth checked regularly. You can also check your mouth yourself in the mirror by looking for changes like a white coating or inflamed areas. Or you can have family members or caregivers help you.

Prevention

If you’re healthy, you don’t have to do anything to prevent oral thrush. But if you are at higher risk, it is especially important to care for your teeth, gums, and the lining of your mouth, and to keep that area moist and protected from injury. A soft-bristled toothbrush is gentle on the gums. Cleaning between your teeth removes plaque and food particles. Dentures should be cleaned regularly, for example with a toothbrush and a special cleaning solution. Anyone who uses steroid sprays should rinse their mouth with water afterward.

Hospital staff will take special care to ensure that people that people with weakened immune systems do not become infected with germs during treatment. Antifungal drugs called antimycotics are used in rare instances to prevent fungal infections. These drugs kill the fungus or reduce its growth. But taking them as a preventive measure is only a good option in certain situations – for example, during a stem cell transplant. It is still important to detect oral thrush early and then have it treated.

Treatment

Oral thrush can be treated very effectively with antimycotics. Some of these medications can be applied directly (topically) to the affected mucous membranes in the mouth – that is often all that is needed for milder oral thrush. Other kinds are swallowed. They then spread through your body (systemic treatment). Small amounts of topically applied medication enter the gastrointestinal tract (stomach and bowel) through saliva. Some of the medication is absorbed there and then also spreads through the body.

But they can have side effects, including headaches, rashes, nausea, flatulence (wind) and diarrhea. Resistance can also develop – meaning that the fungus becomes less sensitive to certain antimycotics. This can make treatment more difficult.

Factors like your general health and how much the has spread will determine which antimycotic is suitable for you. The medications are typically used over a time period of about one to two weeks.

You can also change what you eat so that the mouth sores are less painful – for example, by switching to soft foods, avoiding hot or alcoholic drinks and leaving heavily seasoned or acidic foods out of your diet.

Further information

When people are ill or need medical advice, they usually go to see their family doctor first. Information about health care in Germany can help you to navigate the German healthcare system and find a suitable doctor. You can use this list of questions to prepare for your appointment.

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Cornely OA, Sprute R, Bassetti M et al. Global guideline for the diagnosis and management of candidiasis: an initiative of the ECMM in cooperation with ISHAM and ASM. Lancet Infect Dis 2025; 25(5): e280-e293.

Deutsche Gesellschaft für Hämatologie und Medizinische Onkologie (DGHO). Antimykotische Primärprophylaxe bei Patienten mit hämatologischen Neoplasien (Onkopedia Leitlinien). 2023.

Deutsches Krebsforschungszentrum (DKFZ), Krebsinformationsdienst (KID). Zahnpflege und Mundhygiene. 2022.

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Ramírez-Carmona W, Fernandes GL, Díaz-Fabregat B et al. Effectiveness of fluconazole as antifungal prophylaxis in cancer patients undergoing chemotherapy, radiotherapy, or immunotherapy: systematic review and meta-analysis. APMIS 2023; 131(11): 668-684.

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Taylor M, Brizuela M, Raja A. Oral Candidiasis. In: StatPearls. Treasure Island (FL): StatPearls Publishing; 2023.

Worthington HV, Clarkson JE, Khalid T et al. Interventions for treating oral candidiasis for patients with cancer receiving treatment. Cochrane Database Syst Rev 2010; (7): CD001972.

IQWiG health information is written with the aim of helping people understand the advantages and disadvantages of the main treatment options and health care services.

Because IQWiG is a German institute, some of the information provided here is specific to the German health care system. The suitability of any of the described options in an individual case can be determined by talking to a doctor. informedhealth.org can provide support for talks with doctors and other medical professionals, but cannot replace them. We do not offer individual consultations.

Our information is based on the results of good-quality studies. It is written by a team of health care professionals, scientists and editors, and reviewed by external experts. You can find a detailed description of how our health information is produced and updated in our methods.

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Updated on May 27, 2026

Next planned update: 2029

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Institute for Quality and Efficiency in Health Care (IQWiG, Germany)

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