How can you protect yourself and others from syphilis?

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Condoms can protect you from syphilis, but not one hundred percent. People who are at higher risk of STIs (sexually transmitted infections) should have regular tests so that an can be detected and treated early, and not passed on to others.

Syphilis is passed on through sexual contact. It is caused by that usually first infect the genital area. As time goes by, they spread throughout the whole body. People who are infected can infect others, especially during sex – even if they don’t have any symptoms.

The main way to protect yourself and others from syphilis is to get information and advice on what it is and how it’s spread. Doctors, local health departments and sexual health clinics can help here. Learning more about syphilis and its effects might encourage you to protect yourself – for example, by using condoms or getting tested regularly.

There are no medications that effectively prevent syphilis infections when applied directly to the skin or membranes: Germ-killing gels and vaginal suppositories have not been shown to prevent syphilis in studies. There is no vaccine for syphilis.

How can you protect yourself during sex?

Condoms and femidoms (condoms for women) can stop the spread of STIs like syphilis during sex. When skin rubs on skin, like when the penis enters the vagina or anus, can be passed on through small tears in the skin. Condoms and femidoms create a barrier, preventing in that way. But there may also be tiny tears and small wounds in areas of skin that are not covered by a condom or femidom. If syphilis sores develop in those areas, sexual partners can easily become infected too. These sores can also develop in or around the mouth. So it's advisable to use condoms and special thin sheets (known as dental dams) during oral sex. It is possible to become infected through intense kissing, too.

If you want to share sex toys like dildos, it’s a good idea to put a condom on them, using a new condom each time someone else uses the toy.

When is it a good idea to get tested for syphilis?

Generally speaking, it's best to get tested if you develop typical syphilis symptoms like a painless bump on the penis, vagina, anus or mouth.

But it's sometimes also a good idea to get tested even if you don’t have any symptoms: People who have various different sexual partners and don’t use condoms are more likely to catch STIs like syphilis. People who inject drugs are also advised to get tested even if they don’t have any symptoms. Getting tested regularly (roughly every three months) makes sure that infections don’t go unnoticed and untreated for a long time. Early and treatment also protects your sexual partners.

You can find out where to get tested, and what it involves, here: “When and where can you get tested for syphilis?

What can you do if the test is positive?

If you’re diagnosed with syphilis, there are two main things you need to do: Stop having sex, so you can’t infect anyone. And start treatment with soon. The treatment is usually successful: A long-acting penicillin injection is often all it takes. That is followed by a check-up after four weeks to see if the treatment has worked. If it has, it's usually okay to have sex again. But if you still have symptoms and aren't sure whether the treatment worked, it's better to wait until after your next check-up before having sex again.

There’s no need to disinfect household items or surfaces. You can also carry on doing things like shaking hands, hugging and cuddling – as long as you don't touch the infected person’s sores.

Talking about STIs can be unpleasant or distressing. But it’s still important to tell anyone you might have infected about your . You should at least contact everyone you had sex with in the three months before you were diagnosed with syphilis. If certain symptoms (like warts in the genital area) suggest that you were infected longer ago, you should contact all the sexual partners you had in the last twelve months. Once they know, they can get themselves tested and, if necessary, treated too. Otherwise, you might end up passing the back and forth.

How can unborn babies be protected?

If a pregnant woman has syphilis, she might pass it on to her unborn baby. That often leads to a miscarriage, or the newborn baby may develop the disease in the first few months of their life. To prevent that from happening, every pregnant woman is offered a syphilis test as part of standard prenatal care. Experts recommend getting tested early in pregnancy. If the test result is positive, the can be treated immediately with . In Germany, the fact that you had a syphilis test is noted in your maternity record booklet (“Mutterpass”), but the result is not noted there.

Deutsche STI-Gesellschaft (DSTIG). Diagnostik und Therapie der Syphilis (S2k-Leitlinie). AWMF-Registernr.: 059-002. 2021.

Deutsche STI-Gesellschaft (DSTIG). Sexuell übertragbare Infektionen (STI): Beratung, Diagnostik und Therapie (S2k-Leitlinie). AWMF-Registernr.: 059-006. 2018.

Henderson JT, Henninger M, Bean SL. Behavioral Counseling Interventions to Prevent Sexually Transmitted Infections: A Systematic Evidence Review for the U.S. Preventive Services Task Force (AHRQ Evidence Syntheses; No. 192). 2020.

Nenoff P, Manos A, Ehrhard I et al. Nichtvirale sexuell übertragene Infektionen – Epidemiologie, Klinik, Labordiagnostik und Therapie. Teil 3: Treponemen, Gardnerella und Trichomonaden. Hautarzt 2017; 68(2): 136-148.

Obiero J, Ogongo P, Mwethera PG et al. Topical microbicides for preventing sexually transmitted infections. Cochrane Database Syst Rev 2021; (3): CD007961.

Robert Koch-Institut (RKI). RKI-Ratgeber Syphilis. 2020.

Wiyeh AB, Mome RK, Mahasha PW et al. Effectiveness of the female condom in preventing HIV and sexually transmitted infections: a systematic review and meta-analysis. BMC Public Health 2020; 20(1): 319.

IQWiG health information is written with the aim of helping people understand the advantages and disadvantages of the main treatment options and health care services.

Because IQWiG is a German institute, some of the information provided here is specific to the German health care system. The suitability of any of the described options in an individual case can be determined by talking to a doctor. informedhealth.org can provide support for talks with doctors and other medical professionals, but cannot replace them. We do not offer individual consultations.

Our information is based on the results of good-quality studies. It is written by a team of health care professionals, scientists and editors, and reviewed by external experts. You can find a detailed description of how our health information is produced and updated in our methods.

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Created on July 17, 2023

Next planned update: 2026

Publisher:

Institute for Quality and Efficiency in Health Care (IQWiG, Germany)

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