How effective are antiviral medications for treating the flu?

Photo of a person taking tablets

Some people have an increased risk of serious complications like when they have the flu. Special antiviral medications such as oseltamivir (brand name: Tamiflu) may be an option for them. These medications can help general flu symptoms go away a bit sooner. But they cannot prevent severe cases of the flu.

Influenza or ‘the flu’ is a viral of the upper respiratory tract (a disease of the airways). It can cause various symptoms, including fever, muscle ache, severe tiredness and , a cough and a blocked nose.

Almost everyone who gets the flu is over the worst of it within a week. But they may feel unwell for about one to two weeks after that. A cough can be particularly persistent.

Older people and people with chronic medical conditions are at greater risk of getting very ill if they have the flu. Serious complications such as pneumonia are then more common, and they can also become fatal. Special antiviral medications may be an option for these people. But people who are otherwise healthy are very unlikely to experience serious complications or die of the flu.

Good to know:

The annual flu vaccine is recommended for people who have an increased risk of becoming seriously ill. It can reduce the risk of getting the flu.

What are antiviral medications?

Special antiviral medications can fight against the spread of flu viruses in the body. In Germany, the drugs oseltamivir and zanamivir are commonly used to treat the flu.

Oseltamivir and zanamivir are neuraminidase inhibitors: These drugs aim to block a protein called neuraminidase. Flu viruses need neuraminidase in order to spread in the body. Both of the drugs have to be prescribed by a doctor. This means that you can only get the medication with a prescription. Oseltamivir is the better-known of the two. It is available in Germany under the trade name Tamiflu. Oseltamivir is usually taken in capsule form. Zanamivir (brand name: Relenza) is available as an infusion (a drip) or for inhalation (breathing in). Both medications are commonly taken twice a day for a total of five days.

Good to know:

Antiviral medications may be considered for people who have an increased risk of becomign severely ill, such as older adults with underlying medical conditions or pregnant women. Treatment should be started within one to two days of the first symptoms appearing.

How effective are antiviral medications for treating the flu?

Studies show that antiviral medications can shorten the duration of flu symptoms by a few hours. On average the difference is less than one day.

The studies also found no that antiviral drugs can prevent severe illness or serious complications. It is unclear whether people are less contagious when taking antiviral medications.

The most common side effects of oseltamivir are vomiting and nausea. About 4 out of 100 people are affected. I rare cases, zanamivir causes the airways to narrow or affects the functioning of the lungs. That is why it is especially important for people who have or to carefully weigh the pros and cons together with their doctor.

What can you do yourself about the flu?

A flu usually goes away on its own after about one to three weeks. Symptoms like fever, cough, a runny or stuffy nose, and a sore throat or headache are certainly unpleasant, and they can make you feel really bad. It usually isn’t necessary to take any pills or tablets. If you have the flu, it's most important to get some rest until the symptoms go away. Doctors recommend drinking plenty of fluids, especially if you have a high fever.

Many people also use home remedies such as chicken soup or herbal teas to relieve their symptoms or simply because they find them soothing. And many people also find it pleasant to inhale water vapor, with or without additives. But there's no compelling that these remedies are effective at helping you recover from the flu.

Fever or pain can be reduced with painkillers like acetaminophen, acetylsalicylic acid (ASA, the drug in medicines like Aspirin), and ibuprofen.

Important:

The active ingredient acetylsalicylic acid (ASA) is not suitable for children and teenagers. It can cause a rare but dangerous side effect called Reye’s syndrome in this age group.

You can use a decongestant nasal spray or nose drops for a few days to relieve a stuffy nose. To stop the urge to cough, you can drink fluids to keep your airways moist and avoid possible triggers like dry air or smoke. You could also try herbal remedies, such as extracts of ivy leaf, thyme, or primrose root. They are available from pharmacies without a prescription.

There is a wide variety of over-the-counter remedies for cold and flu symptoms, such as those containing zinc, vitamins or herbal extracts. But there's no compelling that they're effective against the flu.

Antibiotics are only effective against , not against viruses. So can only help with the flu if there is an additional bacterial that is leading to complications. They don't have any benefit otherwise.

Gao Y, Guyatt G, Uyeki TM et al. Antivirals for treatment of severe influenza: a systematic review and network meta-analysis of randomised controlled trials. Lancet 2024; 404(10454): 753-763.

Gao Y, Zhao Y, Liu M et al. Antiviral Medications for Treatment of Nonsevere Influenza: A Systematic Review and Network Meta-Analysis. JAMA Intern Med 2025; 185(3): 293-301.

Hanula R, Bortolussi-Courval E, Mendel A et al. Evaluation of Oseltamivir Used to Prevent Hospitalization in Outpatients With Influenza: A Systematic Review and Meta-Analysis. JAMA Intern Med 2024; 184(1): 18-27.

Jefferson T, Jones MA, Doshi P et al. Neuraminidase inhibitors for preventing and treating influenza in adults and children. Cochrane Database Syst Rev 2014; (4): CD008965.

Robert Koch-Institut (RKI). Influenza (Teil 1): Erkrankungen durch saisonale Influenzaviren. RKI-Ratgeber. 2026.

Tejada S, Jansson M, Solé-Lleonart C et al. Neuraminidase inhibitors are effective and safe in reducing influenza complications: meta-analysis of randomized controlled trials. Eur J Intern Med 2021; 86: 54-65.

World Health Organization (WHO). Clinical practice guidelines for influenza. 2024.

IQWiG health information is written with the aim of helping people understand the advantages and disadvantages of the main treatment options and health care services.

Because IQWiG is a German institute, some of the information provided here is specific to the German health care system. The suitability of any of the described options in an individual case can be determined by talking to a doctor. informedhealth.org can provide support for talks with doctors and other medical professionals, but cannot replace them. We do not offer individual consultations.

Our information is based on the results of good-quality studies. It is written by a team of health care professionals, scientists and editors, and reviewed by external experts. You can find a detailed description of how our health information is produced and updated in our methods.

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Updated on October 1, 2026

Next planned update: 2029

Publisher:

Institute for Quality and Efficiency in Health Care (IQWiG, Germany)

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