The safe use of over-the-counter painkillers

Photo of a woman reading a package insert
PantherMedia / Gabriele Willig

Many painkillers are available from pharmacies without a prescription. They can provide effective pain relief, but might also cause side effects or complications. In order to use them safely, it is important to pay attention to the dose and interactions with other medicinal products.

Over-the-counter painkillers available from pharmacies, such as ibuprofen or acetaminophen (paracetamol), can relieve acute pain. Their effectiveness will depend on things like the type and severity of the pain and the dose of the medication. Painkillers that are available without a prescription have been approved for the treatment of mild to moderate pain. They shouldn't be used for more than a few days in a row, and the specified maximum daily dose shouldn't be exceeded.

Painkillers can have side effects and – in rare cases – lead to complications. In order to avoid adverse effects, it is important to make sure you use them properly. This is particularly true for people who have certain medical conditions or use painkillers regularly. A medication's package insert contains detailed information about its areas of use, the correct doses and how long you can use it for. You can also ask your doctor or pharmacist about how to use it properly.

Which painkillers are available over the counter?

The largest group of over-the-counter painkillers are the non-steroidal (NSAIDs). As their name suggests, they also reduce inflammation but – unlike other anti-inflammatory medicine – do not contain steroids. Over-the-counter NSAIDs are used in the treatment of many different kinds of pain, including headaches, period pain and toothache. NSAIDs reduce pain and and also lower fever.

There are more than ten different NSAIDs, but not all of them are available without a prescription or in every dose. In Germany and other countries, the following NSAIDs are available over the counter:

  • Acetylsalicylic acid (ASA, the drug in medicines like "Aspirin") (in doses of up to 500 mg per tablet)
  • Diclofenac (up to 25 mg per tablet)
  • Ibuprofen (up to 400 mg per tablet)
  • Naproxen (up to 250 mg per tablet)

These medications are also by far the most commonly used NSAIDs.

Acetaminophen (paracetamol) is another very widely used painkiller. While also relieving pain and lowering fever, it doesn't reduce (unlike NSAIDs).

In some medications it is combined with an NSAID (e.g. acetylsalicylic acid and acetaminophen). Caffeine is sometimes added too. It isn't clear whether these kinds of combinations have any advantages or disadvantages over using the active ingredients separately. There are no good-quality studies comparing combination medications with individual drugs.

How do NSAIDs work?

NSAIDs inhibit the action of certain enzymes known as cyclooxygenases or COX enzymes. For this reason, NSAIDs are sometimes also referred to as COX inhibitors. COX enzymes play an important role in the production of known as prostaglandins. There are two different COX enzymes:

  • COX-1 regulates things like the production of the prostaglandins that are needed to keep the lining of your stomach healthy.
  • COX-2 regulates the production of the prostaglandins that are responsible for symptoms of illness such as pain, swelling and fever.

By inhibiting the action of the COX-2 enzyme, NSAIDs can reduce pain, fever and inflammation. But because NSAIDs also inhibit the action of the COX-1 enzyme, they can cause side effects too – particularly affecting the stomach.

It is still not exactly clear how acetaminophen (paracetamol) works. Although there are various theories, none of them fully explain its effect.

What is the right dose?

The risk of side effects and complications can be reduced by using the lowest dose possible. It is generally important not to exceed the maximum single dose or the maximum daily dose. The information in the following table applies to Germany but may be very similar in other countries.

Table: Maximum daily dose for adults (without a prescription)
Drug Maximum single dose Maximum daily dose
ASA 1,000 mg 3,000 mg in people under 65, 2,000 mg in people over 65
Diclofenac 25 mg 75 mg
Ibuprofen 400 mg 1200 mg
Naproxen 500 mg 750 mg
Acetaminophen (paracetamol) 1,000 mg 4,000 mg
Fixed-dose combination of acetylsalicylic acid
(ASA), acetaminophen and caffeine
500 mg ASA / 400 mg acetaminophen/ 100 mg caffeine 1,500 mg ASA / 1200 mg acetaminophen / 300 mg caffeine

So if someone has a packet of 400 mg ibuprofen tablets, for instance, they should not take more than three tablets per day (24 hours).

Different NSAIDs shouldn't be combined with each other. But an NSAID can be combined with acetaminophen if one medication alone isn't effective enough.

What are the side effects and complications?

The most common side effects of NSAIDs affect the stomach. They range from minor problems like indigestion and stomach ache to more serious problems like gastritis, ulcers and bleeding in the stomach or bowel (gastrointestinal bleeding). The risk of complications can be significantly reduced by using other medication to protect the stomach. Proton pump inhibitors such as omeprazole or pantoprazole are typically used for this purpose. But over-the-counter painkillers very rarely lead to serious side effects if they are taken for a short time only.

Several analyses of studies in recent years have also shown that certain NSAIDs, such as diclofenac, increase the risk of cardiovascular (heart and blood vessel) disease. But that is mainly if you take high doses over a long period of time. Nevertheless, it may still be a good idea for people who are at higher risk of cardiovascular disease, or already have cardiovascular disease, to take low doses of ibuprofen or naproxen rather than diclofenac. People who have cardiovascular disease can take acetaminophen (paracetamol) as an alternative to NSAIDs.

Who has a particularly high risk of complications?

A number of personal factors increase the likelihood of NSAIDs causing problems. The risk of developing stomach or bowel problems is greater if you

  • are over the age of 65,
  • currently have a stomach or gastritis, or had one of them in the past,
  • have chronic inflammatory bowel disease (Crohn's disease or ),
  • take several NSAIDs at the same time,
  • are taking low-dose acetysalicylic acid ("Aspirin") to prevent complications following a or stroke,
  • are taking anticoagulant (anti-clotting) medication, steroid medication or SSRI antidepressants.

NSAIDs also increase the risk of heart attacks or strokes, particularly in people who have already had one. These complications are more likely if you already have other kinds of cardiovascular disease or if you have risk factors such as high blood pressure. In people who have decreased kidney function, taking NSAIDs can increase the risk of acute kidney failure. It is especially important for them to avoid taking too high a dose.

When should certain painkillers be avoided?

NSAIDs aren't suitable for people with advanced kidney disease. Acetaminophen (paracetamol) is then an alternative option. People who have a stomach or severe cardiac insufficiency (heart failure) shouldn't take NSAIDs either. Pregnant women are only allowed to take certain NSAIDs during certain weeks of pregnancy. It is best to consult your pharmacist or doctor if you have any questions.

Acetaminophen is not suitable for people who have liver disease. This is because it is broken down by the liver and can cause severe liver damage. It is also not suitable for people who have problems with alcohol abuse. People who have a severely decreased kidney function should wait eight hours between taking the tablets, and make sure they don't take more than 3000 mg acetaminophen per day.

Which symptoms could be signs of complications?

Side effects like mild indigestion are not a cause for concern. But you should see a doctor if you have frequent or severe stomach pain, or if you notice signs of bleeding in the stomach. These include the following:

  • Black-colored stool (bowel movements)
  • Vomit with blood in it (red or black vomit)
  • Anemia symptoms such as exhaustion, shortness of breath during physical activity, or pale skin

In rare cases, ulcers can lead to perforation of the stomach wall (perforated ). This complication is associated with sudden and very strong stomach pain. Perforation of the stomach wall is a life-threatening condition, so these symptoms should be taken seriously and the emergency services should be called immediately.

Knowing the possible signs of a or stroke can also be helpful.

How can complications be prevented?

You can lower the risk of painkiller-related side effects and complications by paying attention to the package insert and

  • always taking "as little as possible, as much as necessary,"
  • only taking painkillers for as long as really needed,
  • watching out for possible interactions with other medications, and
  • checking whether certain painkillers aren't suitable if you have any of the risks or medical conditions described above.

What happens if there are drug-drug interactions?

Painkillers can also interact with other medications. It is called a "drug-drug interaction" if two medications influence each other – for instance, if they increase, weaken or cancel out their effects. As a result, the medications may no longer work properly or the risk of complications might increase.

NSAIDs can interact with various medications. For instance, taking them together with certain medications that suppress the (cyclosporine and tacrolimus) increases the risk of kidney damage. This is also true if you take NSAIDs together with diuretics or certain blood-pressure-lowering drugs (ACE inhibitors and angiotensin II antagonists). NSAIDs can increase the effect of anti-clotting medications (anticoagulants) such as clopidogrel and Marcumar, which may lead to bleeding.

The risk of liver damage is higher if acetaminophen (paracetamol) is taken together with the antibiotic isoniazid. For the same reason, you should avoid drinking alcohol if you take acetaminophen. The cancer medication imatinib might also increase the kidney-damaging effect of acetaminophen. Taking acetaminophen together with anti-clotting medications such as Marcumar increases the risk of bleeding.

The possible drug-drug interactions of a medication are listed in the accompanying package insert. It is best to consult your doctor or pharmacist if you have any questions.

Agency for Healthcare Research and Quality (AHRQ). Aspirin Use in Adults: Cancer, All-Cause Mortality, and Harms: A Systematic Evidence Review for the U.S. Preventive Services Task Force. September 2015 (Evidence Syntheses; Band 132).

Coxib and traditional NSAID Trialists' (CNT) Collaboration, Bhala N, Emberson J, Merhi A, Abramson S, Arber N, Baron JA et al. Vascular and upper gastrointestinal effects of non-steroidal anti-inflammatory drugs: meta-analyses of individual participant data from randomised trials. Lancet 2013; 382(9894): 769-779.

Derry CJ, Derry S, Moore RA. Caffeine as an analgesic adjuvant for acute pain in adults. Cochrane Database Syst Rev 2014; (12): CD009281.

McGettigan P, Henry D. Cardiovascular risk with non-steroidal anti-inflammatory drugs: systematic review of population-based controlled observational studies. PLoS Med 2011; 8(9): e1001098.

Moore RA, Wiffen PJ, Derry S, Maguire T, Roy YM, Tyrrell L. Non-prescription (OTC) oral analgesics for acute pain - an overview of Cochrane reviews. Cochrane Database Syst Rev 2015; (11): CD010794.

IQWiG health information is written with the aim of helping people understand the advantages and disadvantages of the main treatment options and health care services.

Because IQWiG is a German institute, some of the information provided here is specific to the German health care system. The suitability of any of the described options in an individual case can be determined by talking to a doctor. can provide support for talks with doctors and other medical professionals, but cannot replace them. We do not offer individual consultations.

Our information is based on the results of good-quality studies. It is written by a team of health care professionals, scientists and editors, and reviewed by external experts. You can find a detailed description of how our health information is produced and updated in our methods.

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Updated on August 10, 2017
Next planned update: 2021


Institute for Quality and Efficiency in Health Care (IQWiG, Germany)

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