Abraham P, Avenell A, McGeoch SC, Clark LF, Bevan JS. Antithyroid drug regimen for treating Graves' hyperthyroidism. Cochrane Database Syst Rev 2010; (1): CD003420.
Azizi F, Malboosbaf R. Long-Term Antithyroid Drug Treatment: A Systematic Review and Meta-Analysis. Thyroid 2017; 27(10): 1223-1231.
De Leo S, Lee SY, Braverman LE. Hyperthyroidism. Lancet 2016; 388(10047): 906-918.
Deutsche Gesellschaft für Allgemein- und Viszeralchirurgie (DGAV). Operative Therapie benigner Schilddrüsenerkrankungen (S2k). AWMF-Registernr.: 088-007. October 3, 2015.
Deutsche Gesellschaft für Nuklearmedizin (DGN). Radioiodtherapie bei benignen Schilddrüsenerkrankungen (Version 5) - DGN-Handlungsempfehlung (S1-Leitlinie). October 2015.
Jameson JL, Mandel SJ, Weetmann AP. Disorders of the Thyroid Gland. In: D. L. Kaspers, S. L. Hauser, J. L. Jameson, Fauci AS, D. L. Longo, J. Loscalzo (Ed). Harrison's Principles of Internal Medicine. McGraw-Hill Education; 2015.
Kahaly GJ, Bartalena L, Hegedüs L et al. 2018 European Thyroid Association Guideline for the Management of Graves’ Hyperthyroidism. Eur Thyroid J 2018; 7(4): 167-186.
Liu ZW, Masterson L, Fish B, Jani P, Chatterjee K. Thyroid surgery for Graves' disease and Graves' ophthalmopathy. Cochrane Database Syst Rev 2015; (11): CD010576.
Ma C, Xie J, Wang H, Li J, Chen S. Radioiodine therapy versus antithyroid medications for Graves' disease. Cochrane Database Syst Rev 2016; (2): CD010094.
Metso S, Auvinen A, Huhtala H, Salmi J, Oksala H, Jaatinen P. Increased cancer incidence after radioiodine treatment for hyperthyroidism. Cancer 2007; 109(10): 1972-1979.
National Institute for Health and Care Excellence (NICE). Thyroid disease: assessment and management (NICE Guidelines; Volume NG145). 2019.
Ross DS, Burch HB, Cooper DS, Greenlee MC, Laurberg P, Maia AL et al. 2016 American Thyroid Association Guidelines for Diagnosis and Management of Hyperthyroidism and Other Causes of Thyrotoxicosis. Thyroid 2016; 26(10): 1343-1421.
Tu X, Dong Y, Zhang H et al. Corticosteroids for Graves' Ophthalmopathy: Systematic Review and Meta-Analysis. Biomed Res Int 2018: 4845894.
US Food and Drug Administration (FDA). FDA Drug Safety Communication: New Boxed Warning on severe liver injury with propylthiouracil. April 21, 2010.
Walter MA, Briel M, Christ-Crain M, Bonnema SJ, Connell J, Cooper DS et al. Effects of antithyroid drugs on radioiodine treatment: systematic review and meta-analysis of randomised controlled trials. BMJ 2007; 334(7592): 514.
Zhao LQ, Yu DY, Cheng JW. Intravenous glucocorticoids therapy in the treatment of Graves' ophthalmopathy: a systematic review and Meta-analysis. Int J Ophthalmol 2019; 12(7): 1177-1186.
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