Azarpazhooh A, Lawrence HP, Shah PS. Xylitol for preventing acute otitis media in children up to 12 years of age. Cochrane Database Syst Rev 2016; (8): CD007095.
De Sévaux JL, Venekamp RP, Lutje V et al. Pneumococcal conjugate vaccines for preventing acute otitis media in children. Cochrane Database Syst Rev 2020; (11): CD001480.
Gulani A, Sachdev HS. Zinc supplements for preventing otitis media. Cochrane Database Syst Rev 2014; (6): CD006639.
Jones LL, Hassanien A, Cook DG et al. Parental smoking and the risk of middle ear disease in children: a systematic review and meta-analysis. Arch Pediatr Adolesc Med 2012; 166(1): 18-27.
MacKeith S, Mulvaney CA, Galbraith K et al. Ventilation tubes (grommets) for otitis media with effusion (OME) in children. Cochrane Database Syst Rev 2023; (11): CD015215.
MacKeith S, Mulvaney CA, Galbraith K et al. Adenoidectomy for otitis media with effusion (OME) in children. Cochrane Database Syst Rev 2023; 10: CD015252.
Mosquera FE, de la Rosa Caldas M, Naranjo Rojas A et al. Probiotic, Prebiotic, and Synbiotic Supplementation for the Prevention and Treatment of Acute Otitis Media: A Systematic Review and Meta-Analysis. Children 2025; 12(5).
Nelson AM. A comprehensive review of evidence and current recommendations related to pacifier usage. J Pediatr Nurs 2012; 27(6): 690-699.
Norhayati MN, Ho JJ, Azman MY. Influenza vaccines for preventing acute otitis media in infants and children. Cochrane Database Syst Rev 2017; (10): CD010089.
Robert Koch-Institut (RKI). Schutzimpfung gegen Influenza (Grippe). 2026.
Scott AM, Clark J, Julien B et al. Probiotics for preventing acute otitis media in children. Cochrane Database Syst Rev 2019; (6): CD012941.
Steele D, Adam GP, Di M et al. Tympanostomy Tubes in Children with Otitis Media. (AHRQ Comparative Effectiveness Reviews; No. 185). 2017.
Venekamp RP, Mick P, Schilder AG et al. Grommets (ventilation tubes) for recurrent acute otitis media in children. Cochrane Database Syst Rev 2018; (5): CD012017.
IQWiG health information is written with the aim of helping people understand the advantages and disadvantages of the main treatment options and health care services.
Because IQWiG is a German institute, some of the information provided here is specific to the German health care system. The suitability of any of the described options in an individual case can be determined by talking to a doctor. informedhealth.org can provide support for talks with doctors and other medical professionals, but cannot replace them. We do not offer individual consultations.
Our information is based on the results of good-quality studies. It is written by a team of health care professionals, scientists and editors, and reviewed by external experts. You can find a detailed description of how our health information is produced and updated in our methods.