Medication overuse headaches

Photo of an older man taking painkillers

It might sound counterintuitive, but taking painkillers or migraine medication very often can cause more headaches. It is then advisable to completely stop taking the medication for a few days.

Headaches can be a side effect of various medications, including medicine for treating heart problems (nitro spray) or erectile dysfunction (what are known as PDE-5 inhibitors).

People with a primary headache condition such as migraine or tension headaches who regularly and frequently take painkillers or migraine medication may experience more frequent headaches . These kinds of headaches are referred to as "medication overuse" headaches.

Whether the use of medication is actually considered to be "overuse" depends on how many days it was taken over the last three months, and exactly what kind of medication has been used. The dosage on the individual days is less important. Taking painkillers such as paracetamol, acetylsalicylic acid (the drug in medicines like “Aspirin”) or ibuprofen on 15 or more days per month is considered to be overuse. Taking migraine medications such as triptans or ergotamins on ten days per month is already considered to be too much.

Experts assume that about 1 to 2 out of 100 people have headaches because they use painkillers or migraine medication too often. This is most common in middle-aged women who have migraines.

Why can medication overuse cause headaches?

It is not clear what causes these types of headaches. One possibility is that the nervous system gets used to the medications and then reacts even more sensitively to pain stimuli and triggers. In other words, a stimulus that the brain doesn’t normally register as pain is then perceived as being painful. But there are lots of unanswered questions, such as why people who often take painkillers for other illnesses like chronic joint pain don’t get these kinds of headaches.

What are the symptoms of medication overuse headaches?

Medication overuse headaches cause a dull pain that affects the entire head. There are usually no other symptoms. But sometimes people experience an attack of an existing primary headache conditions along with the permanent headache: The pain then caused by migraine, for example, is more of a throbbing pain and other migraine symptoms develop as well. Medication overuse headaches are chronic, meaning that they occur on more than 15 days per month over a period of three months.

What can you do to relieve the headaches?

At first, people with medication overuse headaches often think that their migraine or tension headaches have simply gotten worse. Many of them then start taking more painkillers or migraine medication.

That is why finding out how often you are actually supposed to take the medication is the first step to getting out of this vicious circle. A headache diary and/or medication diary can help with that. You can use it to record when you have had headaches or have taken painkillers. It is then possible to tell if medication overuse might be the reason your “usual” headaches have changed.

Image: Medication diary: Days when medication was taken for headaches are marked with an x.

People who notice that they regularly take painkillers or migraine medication on more than ten days per month should speak to their doctor. It is possible that you might have developed medication overuse headaches in addition to your primary headaches.

Taking a break from using medication

You will then have to stop taking the medication for about 7 to 14 days to diagnose the medication overuse headaches and treat them. If the headaches are caused by medication overuse, the pain gets better and less frequent after a few days. But it can get worse at the beginning of the break before it gets better. Nausea, restlessness, and insomnia are also possible. That's why it's best to plan the break for a time when you are less busy and can talk to your doctor at short notice if needs be. They can then prescribe you with antiemetics against the nausea. Some people also find it helps to dab a little peppermint oil on their forehead or temples. Medications containing cortisone are sometimes used, too. But it would seem that they are no more effective than a placebo at relieving the pain shortly after stopping taking the medication.

A medication break can be done as an outpatient procedure. But it might sometimes be a good idea to stay in hospital, for example if you have already unsuccessfully tried a few times to reduce the amount of painkillers you take. Techniques like cognitive behavioral therapy might be offered in hospital to help with reducing medication.

You can take painkillers or migraine medication again for acute headaches after the medication break. But the rule is always that you shouldn’t take them more than ten days per month and only for three day in a row at most. Lots of people relapse within the first year after stopping the medication and then start taking them more regularly again. That is why it is important to stay in contact with your doctor after successfully stopping.

Preventive treatment

Preventive treatment (prophylactic therapy) is another option if you don't want to stop taking medication. Products such as topiramate or botulinum toxin type A are then taken as a preventive measure for migraine, or amitriptyline for tension headaches. The aim of preventive treatment is to prevent the pain attacks and make sure that painkillers or migraine medication are not needed on more than ten days per month.

Chiang CC, Schwedt TJ, Wang SJ et al. Treatment of medication-overuse headache: A systematic review. Cephalalgia 2016; 36(4): 371-386.

De Goffau MJ, Klaver AR, Willemsen MG et al. The Effectiveness of Treatments for Patients With Medication Overuse Headache: A Systematic Review and Meta-Analysis. J Pain 2017; 18(6): 615-627.

Evers S, Marziniak M. Clinical features, pathophysiology, and treatment of medication-overuse headache. Lancet Neurol 2010; 9(4): 391-401.

Hacke W. Neurologie. Berlin: Springer; 2016.

International Headache Society (IHS). Die Internationalen Klassifikation von Kopfschmerzerkrankungen, 3. Auflage – ICHD-3. 2018.

Westergaard ML, Hansen EH, Glümer C et al. Definitions of medication-overuse headache in population-based studies and their implications on prevalence estimates: a systematic review. Cephalalgia 2014; 34(6): 409-425.

IQWiG health information is written with the aim of helping people understand the advantages and disadvantages of the main treatment options and health care services.

Because IQWiG is a German institute, some of the information provided here is specific to the German health care system. The suitability of any of the described options in an individual case can be determined by talking to a doctor. informedhealth.org can provide support for talks with doctors and other medical professionals, but cannot replace them. We do not offer individual consultations.

Our information is based on the results of good-quality studies. It is written by a team of health care professionals, scientists and editors, and reviewed by external experts. You can find a detailed description of how our health information is produced and updated in our methods.

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Created on April 14, 2023

Next planned update: 2026

Publisher:

Institute for Quality and Efficiency in Health Care (IQWiG, Germany)

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