Diagnostic tests for metastatic breast cancer

Photo of a patient having a mammogram

A number of different tests and examinations can be used to detect breast cancer or metastatic tumors in the body. They are often combined to get a more accurate . The treatment approach can then be chosen based on the findings.

If you think that the breast cancer is progressing, coming back (recurrence) or spreading, the first thing to do is to contact your family doctor or gynecologist, or go to an outpatient practice that specializes in cancer treatment (oncology practice). Different types of tests and procedures might be needed, depending on your symptoms. Your doctor might examine you, or refer you to a hospital or specialized breast cancer center.

A breast cancer center is a specialized hospital department or several specialized departments that work together. In Germany, special “certified” breast cancer centers (Brustzentrum or Tumorzentrum) examine, treat and care for people who have cancer according to special criteria. Specialists working in breast cancer centers include gynecologists, oncologists, psycho-oncologists, nurses and other medical professionals.

What happens before the examinations?

Before doing any examinations, the doctor will always ask you about your symptoms, your general health and medical history. Then the doctor should take the time to carefully explain the following things:

  • Why the examination needs to be done
  • How it’s done
  • What you can find out by doing it
  • Whether it’s associated with any risks or side effects (e.g. a wound after minor surgery or exposure to radiation)
  • What other kinds of examinations are possible
  • What can be done if you decide not to have the examinations
  • When you will get the results and discuss them

As a patient, you always have the right to be given information about these things, and to decide not to have a test that is recommended.

What examinations are done if it’s thought you might have breast cancer?

The following tests are often used to diagnose breast cancer or check whether a tumor in the breast has come back:

  • Examination by hand (palpation) – of the breast, surgery scar and armpits
  • Chest x-ray (mammography)
  • Ultrasound ()
  • Magnetic resonance imaging (MRI, MRT)

In all these examinations, the second breast is examined too. If there’s an abnormal lump, the doctor will usually take a tissue sample (biopsy). A laboratory will then test this sample to find out whether it’s cancerous.

Good to know:

If there are cancer cells in the sample, it’s called a “positive result.”

Possible metastases: What examinations might be done?

If you have general symptoms or if breast cancer has been diagnosed (again), your doctor will check whether the tumor has also spread to other parts of your body. The following imaging techniques can be used for this purpose:

  • Chest x-ray
  • Bone scan (bone scintigraphy)
  • Ultrasound of the liver
  • Computed tomography (CT) scan

If these tests find anything abnormal or if the results are not clear, then doctors will examine the affected part of the body more closely. This may be done using more x-rays, (MRI) and, in some situations, positron emission tomography (). Some devices combine and (/ CT). If possible, a tissue sample will be taken and examined in a laboratory (biopsy) to look for cancer cells.

Your doctor will help you decide which diagnostic tests and procedures make sense and are most suitable for you.

How are tumors classified?

After the examinations are done, the doctor can assess how far the cancer has progressed.

Location, size and degree of spreading

In Germany and many other countries, tumors are usually classified according to the TNM staging system:

Table: Classification of the tumor
Characteristics Abbreviation What it means
Tumor size
(T = tumor)
T0 No tumor was found
  T1 The tumor is 2 cm (centimeters) in diameter or smaller
  T2 The tumor is between 2 and 5 cm in diameter
  T3 The tumor is more than 5 cm in diameter
  T4 Independent of size, the tumor has spread to the chest wall below, or into the skin
Lymph nodes
(N = node)
N0 There are no tumors in the lymph nodes
  N1 to N3 The numbers 1 to 3 stand for location and number of affected regional lymph nodes. Tumors found in lymph nodes that are not in the drainage area of the affected organ are regarded as distant metastases.
(Distant) metastatic tumors
(M = metastatic tumors)
M0 No metastatic tumors were found
  M1 (Distant) metastatic tumors were found
Assessment X The characteristic can't be assessed. This may be because it has not been examined or there are no clear results (for instance: NX = lymph node involvement can't be assessed).

The following abbreviations can be added to the basic TNM classification to provide more information:

  • c (for “clinical”) indicates that the is based on a physical examination or symptoms.
  • p (for “pathological”) means that the is based on tissue tested in a laboratory.
  • r (for “recurrence”) means that a tumor has reappeared.
  • y indicates that the tumor has already been treated with chemotherapy.

The tumor stage is then determined based on this information about the location and size of the tumor, the degree of spreading, and other test results. Tumors are classified as stage 0, I, II, III or IV. Stage 0 means there are abnormal tissue changes that are considered to be early stages of cancer, and stage IV means the cancer has spread.

Tumor growth

In a process called , tumor cells from the tissue sample are examined under a microscope to see how much they differ from healthy cells. The basic rule of thumb is that the more they have mutated, the faster they can grow and penetrate surrounding tissue. The grades G1 to G3 are used to describe tumor cells. The higher the grade, the more malignant the tumor – and the faster it will usually grow.

The influence of hormones

The female sex estrogen and progesterone promote the growth of healthy breast tissue. They can also speed up the growth of cancer cells, which originally stem from healthy tissue. But the only have this effect if the cancer cells have certain receptors (places where the can latch on to). These receptors can be detected in laboratory tests. The hormone receptor status indicates whether or not the cancer cells have these receptors. If they do, the status is “positive.” In this case, tumor growth can usually be slowed down using hormone therapy.

The effect of growth factors

Human epidermal growth factor receptors (HERs) are proteins found on the cell surface. They pass on signals to the inside of the cell, telling it to divide. If a cell has many HERs, it will multiply more often. If cancer cells have a lot of type 2 HERs (called HER2 receptors), the HER2 status is “positive.” Then the growth of the cancer cells can be slowed down with treatments that influence .

Other factors that have an influence

The following information is also important for the doctor:

  • If you have had breast cancer before: How was the tumor classified? How was it treated? How effective were the various treatments? When did you first have breast cancer?
  • How old are you and have you gone through menopause?
  • How is your general health?
  • Do you have any other illnesses?
  • Do you take any medication regularly?

Who can answer questions about the diagnosis?

It is quite normal not to remember all of the important information shortly after receiving such an upsetting . It is also common to feel scared and confused, and need some time to come to terms with the news. It can then be a good idea to make an appointment with your doctor to discuss any questions you still have. Writing down questions before seeing the doctor can help you to remember what you want to ask about. You could also invite a friend, relative or partner to come along. Joining a support group to share experiences with other women in a similar situation can help a lot too.

You can always get a second opinion from a different doctor. This is fairly common, and you can decide whether or not to tell the first doctor that you're getting a second opinion. In Germany, statutory health insurers will usually cover the costs of getting a second opinion. But you can contact your insurer to double-check.

How is the treatment planned?

There are often several different treatment options once the has been made. Breast cancer treatment is almost never urgently needed, so you will have time to consider the different options. Specialized doctors – for instance, at a certified breast cancer center – will usually draw up a treatment plan for metastatic breast cancer. It is up to you whether you want to decide on a treatment together with your doctor or whether you would prefer to leave the decision up to them. Not having any treatment or only having a part of the treatment may also be an option. Maintaining a good quality of life for as long as possible is more important to some women than having targeted cancer therapy.

The following questions might help you to make a decision about whether to have treatment:

  • How could the treatment improve your health?
  • What are the possible side effects?
  • How would the therapy influence your quality of life? How would it affect your career, everyday life and family?
  • What other treatment options are available? How do their pros and cons compare?
  • What would happen if you decide not to have the cancer treated for now? What would the likely course of the disease be then?
  • Are there any clinical trials testing new medications for women with metastatic breast cancer that may be an option for you?

If you think you still need more information, don't hesitate to ask your doctor.

The importance of trust

Talking with doctors, family members and friends can help you to find answers to any questions you may still have. You can also talk to a psycho-oncologist or psychologist, or ask women who have been in a similar situation about their experiences – for example, in a support group for women with metastatic breast cancer.

A trusting relationship with your doctors is a vital part of your treatment. Many women want to discuss the next steps of treatment with the same doctor. But others might feel that their doctor isn’t taking enough time to help them with questions or anxieties, or isn’t taking their own wishes into consideration when it comes to the treatment decision.

Even though this might come as a surprise, some doctors also find it very hard to deal with knowing that their patient has metastatic breast cancer and that there's probably no way to fully cure it. They might overcompensate by taking too much action (too many treatments and examinations) or avoiding longer talks. If you think that might be the case with your doctor, and you don’t feel like you’re in good hands because of it, you can bring it up with them or see another doctor.

Arbeitsgemeinschaft der Wissenschaftlichen Medizinischen Fachgesellschaften (AWMF), Deutsche Krebsgesellschaft (DKG), Deutsche Krebshilfe. Brustkrebs II: Die fortgeschrittene Erkrankung, Rezidiv und Metastasierung. (Leitlinienprogramm Onkologie, in Überarbeitung). AWMF-Registernr.: 032-045OL. 2011.

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Lewis S, Yee J, Kilbreath S et al. A qualitative study of women's experiences of healthcare, treatment and support for metastatic breast cancer. Breast 2015; 24(3): 242-247.

Lück HJ. Systemische Therapie des metastasierten Mammakarzinoms. In: Kreienberg R, Möbus V, Jonat W et al. (Ed). Mammakarzinom: interdisziplinär. Berlin: Springer; 2010. P. 228-246.

National Institute for Health and Care Excellence (NICE). Advanced Breast Cancer: Diagnosis and Treatment. (NICE Clinical Guidelines; No. 81). 2017.

Svensson H, Brandberg Y, Einbeigi Z et al. Psychological reactions to progression of metastatic breast cancer: an interview study. Cancer Nurs 2009; 32(1): 55-63.

IQWiG health information is written with the aim of helping people understand the advantages and disadvantages of the main treatment options and health care services.

Because IQWiG is a German institute, some of the information provided here is specific to the German health care system. The suitability of any of the described options in an individual case can be determined by talking to a doctor. informedhealth.org can provide support for talks with doctors and other medical professionals, but cannot replace them. We do not offer individual consultations.

Our information is based on the results of good-quality studies. It is written by a team of health care professionals, scientists and editors, and reviewed by external experts. You can find a detailed description of how our health information is produced and updated in our methods.

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Updated on January 23, 2024

Next planned update: 2027


Institute for Quality and Efficiency in Health Care (IQWiG, Germany)

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